Document Type : Original Article
Authors
- Mehran Afrashi 1
- Dariush Semnani 1
- Farzaneh Alihosseini 1
- Parvin Dehghan 2
- Mehrnoush Maheronnaghsh 2
1 Department of Textile Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
2 Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
In this research, the anti-fungal effect of fluconazoleloaded polyvinyl alcohol (PVA) nano-fibers was compared with that of drug-loaded fabric (DLF) to be used in medical textiles and fibrous pads as a local drug delivery system. The drug-loaded nano-fibers (DLNs) were coated on the fabric surface using the electro-spinning process. The DLF was then prepared by means of the pad-dry method. The characterization of the samples was carried out by SEM, FTIR, and XRD tests. UV-V is spectrophotometry was also used to measure the drug release rate. The anti-fungal effect was studied by the disk diffusion method. The drug release test showed about 75% fluconazole release in 90 min and the disc diffusion test indicated that the DLF has more effect than the DLN due to the fast drug release.
Keywords
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